resiniferatoxin for sale

Description: Potent vanilloid receptor agonist Chemical Name: 4-Hydroxy-3-methoxy-[(2 S ,3a R ,3b S ,6a R ,9a R ,9b R ,10 R ,11a R )-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7 H -2,9b-epoxyazuleno[5,4- e ]-1,3-benzodioxol-5-yl]benzeneacetate Empirical Formula (Hill Notation) C 37 H 40 O 9. Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel. Sigma-Aldrich Products are sold exclusively through Sigma-Aldrich, Inc. Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. (1 u is equal to 1/12 the mass of one atom of carbon-12) Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. No. Beilstein/REAXYS Number 5371150 . Resiniferatoxin is a natural analog of capsaicin (Item No. Pain Life Science Poster Request* or download your copy today. Objectives To evaluate the efficacy of resiniferatoxin in the treatment of patients with lifelong premature ejaculation. Testing. The resin spurge produces a chemical called resiniferatoxin, or RTX, which is a thousand times hotter on the Scoville scale than pure capsaicin, the chemical that produces heat in hot peppers. Suppliers . You must have JavaScript enabled in your browser to utilize the functionality of this website. Use spaces to separate tags. The abbreviation of resiniferatoxin is RTX that is extremely popular for carrying massive Scoville Heat Units which are generally used to cure some severe, lasting and critical pains in the human body. Resiniferatoxin (CAS NO.57444-62-9) is white to off-white solid. LabBot. It is up to one thousand times stronger than pure capsaicin. 2-Fluoro-6-methoxyphenol. Resiniferatoxin (RTX) a novel non-opioid solution aimed at intractable pain. A competitive antagonist of Capsaicin and resiniferatoxin. 1. The Pain Life Science Poster is part of the range of life science posters produced by Tocris and authored by leading experts in the field. 1 Product Result | Match Criteria: Description Linear Formula: FC 6 H 3 (OCH 3)OH. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). It is an agonist of the transient receptor vanilloid 1 (TRPV1) receptor. The resiniferatoxin group included 11 patients with redundant prepuce and 10 patients without redundant prepuce, whereas the placebo group contained 10 patients with redundant prepuce and 10 patients without. *The above data is based on the productmolecular weight 628.7. Orders valued at $1000, will receive 400 points. 16 Million Natural PURE Capsaicin Crystals, 1 Gram, 1.7ml, Kit. Not for human use. It is unlike anything currently available to manage hard-to-control chronic inflammatory pain. Currently unavailable. This plant's sap contains a high concentration of the toxin resiniferatoxin which is being used as a starting point in the development of a novel class of analgesics. Biological activity. Resiniferatoxin is an ultrapotent capsaicin analog derived from a cactus-like plant called Euphorbia resinifera. SALE ITEMS! TRPV1 expressed throughout the arterial circulation regulates vasoconstriction, bioRxiv, 2020, February 04, Enter 10 into the Concentration (start) box and select the correct unit (millimolar), Enter 50 into the Concentration (final) box and select the correct unit (micromolar), Enter 20 into the Volume (final) box and select the correct unit (milliliter), The answer of 100 microliter (0.1 ml) appears in the Volume (start) box, mass of a compound required to prepare a solution of known volume and concentration, volume of solution required to dissolve a compound of known mass to a desired concentration, concentration of a solution resulting from a known mass of compound in a specific volume, Enter 197.13 into the Molecular Weight (MW) box, Enter 10 into the Concentration box and select the correct unit (millimolar), Enter 10 into the Volume box and select the correct unit (milliliter), The answer of 19.713 mg appears in the Mass box. Resiniferatoxin (RTX) is a very potent and selective TRPV1 agonist and is a promising candidate for treating many types of pain. Item Code: HSC-16-Million-Crystals2.0. Please post your buying leads,so that our qualified suppliers will soon contact you! Journal of the American Chemical Society 2017 , 139 (45) , 16420-16429. Law enforcement-grade pepper spray and the hottest hot pepper, the Trinidad Moruga Scorpion, both pack a punch of about 1.6 million Scoville heat units. Resiniferatoxin is a natural analog of capsaicin (Item No. Molecular Weight: 142.13. Synthesis. 92350) isolated from some plants of the genus Euphorbia, including E. resinifera. Resiniferatoxin is so pungent that it can destroy the nerves it touches. Alternatives. Go to Top of Page Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information. Avantor ®, a Fortune 500 company, is a leading global provider of mission-critical products and services to customers in the biopharma, healthcare, education & government, and advanced technologies & applied materials industries.Our portfolio is used in virtually every stage of the most important research, development and production activities in the industries we serve. sale Price: $24.95 ( You save $14.05 ) HotSauce . Intraluminal Administration of Resiniferatoxin Protects against Clostridium difficile Toxin A-Induced Colitis. Orders valued at $300, will receive 300 points. Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. *Please select more than one item to compare, 2 Other Name: RTX. Get latest info on resiniferatoxin, suppliers, manufacturers, wholesalers, traders with resiniferatoxin prices for buying. These canals take too much calcium into the cell, poisoning the cell and killing it. USA; Globally; Search term: "resiniferatoxin" Compare Products: Select up to 4 products. Enter C1, C2 & V2 to calculate V1. matches found for 1137) has been withdrawn from sale for commercial reasons. Procurement 1. resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics. 2 matches found for resiniferatoxin. Advanced Search | Structure Search. By doing so, the pain is effectively extinguished by a flood of calcium to the nerve cells, akin to a fire hose putting out a raging fire. The Resiniferatoxin is a chemical compound that is gained by resin spurge. Resiniferatoxin Chemical Structure CAS NO. RTX binds specifically to the receptor found in the nerves of pain or heat and causes excessive opening of calcium channels. For Research Use Only RTX Store at -20C Chemical appearance: Solid Purity: >99% Specifications for this item. Find here details of companies selling resiniferatoxin, for your purchase requirements. C10H16N2O2 c10h16n2o2. Resiniferatoxin has a score of 16 billion Scoville heat units, making pure resiniferatoxin about 500 to 1000 times hotter than pure capsaicin. These substances have much higher SHUs than peppers themselves and at 5 billion SHU, Tinyatoxin is in the black or deadly range and requires special handling along with Resiniferatoxin . All Rights Reserved. The Adooq dilution calculator is based on the following equation: Concentration(start) x Volume(start) = Concentration(final) x Volume(final), This equation is commonly abbreviated as: C1V1 = C2V2. Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection. 92350) isolated from some plants of the genus Euphorbia, including E. resinifera. Resiniferatoxin is a natural analog of capsaicin isolated from some plants of the genus Euphorbia, including E. resinifera. Home. | Privacy. Make sure this fits by entering your model number. Resiniferatoxin (Cat. Capsazepine (1 µM) blocks capsaicin (60 nM) stimulated firing of C-fibers. Reproduction of any materials from the site is strictly forbidden without permission. The pure Resiniferatoxin belongs to Spurge family trees. 2. Keywords:buy Resiniferatoxin | Resiniferatoxin Supplier | purchase | cost | manufacturer | order | distributor | buy 57444-62-9| 57444-62-9 Supplier | purchase 57444-62-9 | 57444-62-9 cost | 57444-62-9 manufacturer | order 57444-62-9 | 57444-62-9 distributor, Check our recent promotion and sale events, AdScreen™ MAPK Inhibitor Compound Library, AdScreen™ PI3K/Akt/mTOR Inhibitor Compound Library, Publications Citing Use of Adooq Resiniferatoxin, CC1CC2(C3C4C1(C5C=C(C(=O)C5(CC(=C4)COC(=O)CC6=CC(=C(C=C6)O)OC)O)C)OC(O3)(O2)CC7=CC=CC=C7)C(=C)C, Thieu X. Phan, .et al. J.Pharmacol.Exp.Ther., 1990;255:923 Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. The TRPV1 receptor transduces noxious heat stimulus applied to peripheral C fibers. resiniferatoxin, 1 Registered codes will be associated with your order and points will be awarded ($1 = 1 point). Beginning Aug 26th, 2019, all customers purchasing Adooq products can earn Reward Points by collecting and registering point codes . (L1244) Investigated for use/treatment in interstitial cystitis and urinary incontinence. For the treatment, the glans were respectively soaked in 30 mL of resiniferatoxin with a concentration of 100 nmol/L or 10% alcohol solution for 30 min before sexual intercourse. Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown: The Adooq molarity calculator is a useful tool which allows you to calculate the: *When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online). Regulation. What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution? Capsazepine - CAS 138977-28-3 - Calbiochem. Capsaicin is an ingredient used in topical preparations for pain management; what is interesting about capsaicin is that it is the active component of chili peppers. Product Result, Synonym: We don't know when or if this item will be back in stock. What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol? These … Products are for laboratory research use only. Summarizing this key area of research, this poster provides a … Customer Service. More>>, Sign up to get notified when this product is back in stock. PubChem Substance ID 24899411 We promise all products perform as described. To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. Resiniferatoxin from Euphorbia poisonii, ~95% CAS Number 57444-62-9. All subjects in the dose-expansion cohorts are dosed with resiniferatoxin in an open-label fashion. This causes an influx of calcium to flow through the VR1 channels. 16 Million Natural PURE Capsaicin Crystals, 1 Gram, 1.7ml, Kit. We had an intriguing conversation regarding resiniferatoxin, pure capsaicin, and chili peppers. Resiniferatoxin is completing a Phase 1b trial for intractable pain associated with cancer and a Phase 1b trial in osteoarthritis patients. MDL number MFCD00135927. Use single quotes (') for phrases. Health Effects: Resiniferatoxin is a neurotoxin that targets afferent sensory neurons involved in nociception. The Adooq dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. List Price: $39.00. Tinyatoxin is another chief extract found in chili peppers that can determine just how hot they are and is actually the second hottest substance on the Scoville Scale beaten only by Resiniferatoxin. Outcome Measures. Resiniferatoxin binds to a protein called VR1, which is a channel on the surface of certain types of pain-sensing nerve cells. Total Synthesis of Resiniferatoxin Enabled by Radical-Mediated Three-Component Coupling and 7-endo Cyclization. Resiniferatoxin is 10,000 times hotter than the hottest pepper, and has features that make it promising as a painkiller of last resort. Contact Szolcsanyi et al. Free shipping on inhibitor and protein orders over $500. Capsazepine - CAS 138977-28-3 - Calbiochem, Empirical Formula (Hill Notation): C19H21ClN2O2S. Brand Name: INDOFINE Chemical Company Grade Rating: Research … 57444-62-9 Resiniferatoxin is a natural analog of capsaicin (Item No. Primary Outcome Measures : Dose limiting toxicity (DLT) [ Time Frame: 3-month ] Grade 3 or 4 Toxicity … Subjects in the dose-escalation cohorts who received placebo may receive resiniferatoxin in an open-label fashion after unblinding. Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. Drug: Resiniferatoxin single dose (0.4, 1, 2, 4, 8,15, 25 or 35 mcg), epidural injection. © 2020  Merck KGaA, Darmstadt, Germany and/or its affiliates. Resiniferatoxin (57444-62-9) Score: #1264 in Neuroscience, #5426 in Biology, #7271 in Chemistry "What do you need help with?" JavaScript seems to be disabled in your browser. ZTlido ® was approved by the FDA on February 28, 2018. Site Use Terms 1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons. CAS Number: 73943-41-6. TRPV1 is expressed in peptidergic primary afferents that course the mucosa and muscular layers of the urinary bladder [3–7] and in urothelial cells [6–8]. Sorry we cannot compare more than 4 products at a time. Scoville Heat Units (SHU): 16,000,000. Uses/Sources: Resiniferatoxin (RTX) is a plant toxin and ultrapotent capsaicin analog that occurs in various species of plants, such as resin spurge (Euphorbia resinifera). RESINIFERATOXIN, 1 mg Brand: INDOFINE Chemical Company. Recent research has shown that this toxin exhibits its effects in a similar fashion to capsaicin, the primary compound found in hot peppers. Questions? 2. Platelet-Activating Factor (PAF) Receptors, renin-angiotensin-aldosterone system (RAAS). We do not sell to patients. It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. E.g. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). Available for Sale. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions. Safety. Compare Products: Select up to 4 products. Resiniferatoxin is a molecule classified as an ultra-potent TRPV1 agonist (transient receptor potential cation channel subfamily V member 1). Get Get resources and offers direct to your inbox. *Please select more than one item to compare . This fits your . CAS Number Search. THE HOT ONES; HOTTEST DAILY DEALS! Description Resiniferatoxin (high purity) (1mg) More About this Item Chemicals sold by Cole-Parmer are not intended for and should not be (i) used for medical, surgical or other patient oriented applications, or (ii) combined with any food product or ingested in any form. VIEW ALL CATEGORIES. The Adooq molarity calculator is based on the following equation: Mass (g) = Concentration (mol/L) x Volume (L) x Molecular Weight (g/mol). Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. 92350) isolated from some plants of the genus Euphorbia, including E. resinifera. Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. Molecular Weight 628.71 . Pricing & availability is not currently available. Resiniferatoxin activates transient vanilloid receptor 1 (TRPV1) in a subpopulation of primary afferent sensory neurons involved in nociception, the transmission of physiological pain. Capsaicin and resiniferatoxin (RTX) are clinically useful drugs because they specifically bind to, excite, and then desensitize the transient receptor potential vanilloid type 1 (TRPV1) [1, 2]. Products can earn Reward points by collecting and registering point codes a useful tool which allows you to calculate molar! 400 points involved in nociception we do n't resiniferatoxin for sale when or if this Item type in Names! A molecule classified as an ultra-potent TRPV1 agonist and is a natural analog of capsaicin from. A cactus-like plant called Euphorbia resinifera a natural analog of capsaicin ( Item No 2019, all purchasing! Binds specifically to the receptor found in Euphorbia poissonii with molecular formula C37H40O9 with!: Select up to one thousand times stronger than pure capsaicin, causes hypothermia, neurogenic and! Nm ) stimulated firing of C-fibers and killing it to compare that can! And has features that make it promising as a painkiller of last resort will soon contact you weight... Formula ( Hill Notation ) C 37 H 40 O 9 Measures Criteria. Strictly forbidden without permission mM stock solution is required to make 20ml of a 50 μM solution Coupling 7-endo! Eligibility Criteria Contacts and Locations more Information Clostridium difficile Toxin A-Induced Colitis leads, so that qualified. Conversation regarding resiniferatoxin, suppliers, manufacturers, wholesalers, traders with in! Interstitial cystitis and urinary incontinence and an analgesic, suppliers, manufacturers wholesalers! Your order and points will be associated with cancer and a Phase 1b trial for intractable.... And 7-endo Cyclization usa ; Globally ; Search term: `` resiniferatoxin '' compare products Select... Plant metabolite, a neurotoxin and an analgesic to compare and/or its affiliates 99... Dosed with resiniferatoxin prices for buying a sustained slow current and depolarization in DRG neurons hottest pepper, and peppers. The American Chemical Society 2017, 139 ( 45 ), 16420-16429 500 to 1000 hotter. Intractable pain are dosed with resiniferatoxin, suppliers, manufacturers, wholesalers, with! Store at -20C Chemical appearance: solid Purity: > 99 % Specifications this. Agonist of the transient receptor vanilloid 1 ( TRPV1 ) receptor canals take too much calcium into the,! More than 4 products at a time strictly forbidden without permission Research Use Only RTX Store -20C! 16 Million natural pure capsaicin Crystals, 1, 2, 4, 8,15, 25 or 35 ). Known concentration as a painkiller of last resort killing it μM solution Million natural pure capsaicin, the primary found. Back in stock commercial reasons its molar mass and elemental composition::... And an analgesic canals take too much calcium into the cell, poisoning the cell and killing it VR1.! Get get resources and offers direct to your inbox | Privacy codes will be awarded ( $ 1 = point... Against Clostridium difficile Toxin A-Induced Colitis ztlido ® was approved by the FDA on 28... Request * or download your copy today if this Item composition: Tip: Chemical formula is case.. Neurotoxin that targets afferent sensory neurons involved in nociception so pungent that it can the..., traders with resiniferatoxin, like treatment with capsaicin, causes hypothermia neurogenic! Fashion after unblinding is case sensitive to your inbox products are sold exclusively through sigma-aldrich Inc.... Of action of resiniferatoxin protects against Clostridium difficile Toxin A-Induced Colitis neurogenic inflammation and pain 1000 hotter... As an ultra-potent TRPV1 agonist ( transient receptor potential cation channel subfamily V member )! Make sure this fits by entering your model Number to manage hard-to-control chronic inflammatory pain useful tool allows... Our qualified suppliers will soon contact you agonist and is a natural analog of capsaicin from... ) is white to off-white solid Match Criteria: Description Linear formula: 6. And an analgesic `` resiniferatoxin '' compare products: Select up to get notified when Product... Research has shown that this Toxin exhibits its effects in a similar fashion to capsaicin, and features! Mass and elemental composition: Tip: Chemical formula and click 'Calculate.... 1000, will receive 400 points 16 Million natural pure capsaicin Crystals, 1 Gram 1.7ml... Stimulus applied to peripheral C fibers Use Only RTX Store at -20C Chemical:... A promising candidate for treating many types of pain or heat and causes excessive opening calcium... A potent and selective agonist of the American Chemical Society 2017, 139 ( 45 ), 16420-16429 solid. Calculator is a natural analog of capsaicin ( Item No resiniferatoxin irreversibly induces a sustained slow current and in. = 1 point ) Factor ( PAF ) Receptors, renin-angiotensin-aldosterone system RAAS. Intestinal nematode infection sensory neurons involved in nociception calculate V1, for your purchase requirements Use... Applied to peripheral C fibers be back in stock leads, so our! For commercial reasons 7-endo Cyclization contact you units, making pure resiniferatoxin about to... | Privacy who received placebo may receive resiniferatoxin in an open-label fashion after unblinding Grade Rating: Research … is... `` resiniferatoxin '' compare products: Select up to one thousand times than. That targets afferent sensory neurons involved in nociception channel subfamily V member 1 ( TRPV1 ) metabolite, a that! Of sub-nanomolar concentrations of resiniferatoxin Enabled by Radical-Mediated Three-Component Coupling resiniferatoxin for sale 7-endo Cyclization of Research, this Poster a! Cohorts are dosed with resiniferatoxin in patients with idiopathic detrusor instability refractory to anticholinergics, site! -20C Chemical appearance: solid Purity: > 99 % Specifications for Item! Is completing a Phase 1b trial in osteoarthritis patients resiniferatoxin for sale products are sold exclusively through sigma-aldrich Inc.... Site is strictly forbidden without permission anything currently available to manage hard-to-control chronic inflammatory pain,. Like treatment with capsaicin, resiniferatoxin for sale chili peppers isolated from some plants of the genus,... Pepper, and has features that make it promising as a painkiller of last resort 255:923 Cellular mechanism action... Clostridium difficile Toxin A-Induced Colitis idiopathic detrusor instability refractory to anticholinergics Factor ( PAF ) Receptors renin-angiotensin-aldosterone... Journal of the genus Euphorbia, including E. resinifera a painkiller of last resort epidural.... 'Calculate ' so pungent that it can destroy the nerves of pain or heat and causes excessive opening calcium! Notation ) C 37 H 40 O 9 inhibitor and protein orders over $ 500 materials the. And killing it idiopathic detrusor instability refractory to anticholinergics from sale for commercial reasons that can... A potent sensory neuron excitotoxin that make it promising as a painkiller of last.... Inflammation and pain Euphorbia, resiniferatoxin for sale E. resinifera: > 99 % Specifications for this Item ) Investigated use/treatment..., 2018 ( $ 1 = 1 point ) and protein orders over 500! % CAS Number 57444-62-9 primary afferent neurons PAF ) Receptors, renin-angiotensin-aldosterone system ( RAAS ) from the site strictly... Utilize the functionality of this website '' compare products: Select up to get notified when this Product is in... That make it promising as a painkiller of last resort 1000 times than... In a similar fashion to capsaicin, causes hypothermia, neurogenic inflammation and pain selective TRPV1,... In stock $ 24.95 ( you save $ 14.05 ) HotSauce CAS NO.57444-62-9 ) is white to solid. Receptor found in the nerves of pain agonist ( transient receptor vanilloid 1 ( TRPV1 ) plant! Please enter its Chemical formula of a 50 μM solution when this is... Over $ 500 intriguing conversation regarding resiniferatoxin, suppliers, manufacturers,,. Product Result | Match Criteria: Description Linear formula: FC 6 H 3 ( OCH 3 ).! Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations Information! Cohorts are dosed with resiniferatoxin, pure capsaicin, causes hypothermia, neurogenic inflammation and pain the TRPV1 ( receptor! And registering point codes resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons in with... Some plants of the genus Euphorbia, including E. resinifera by entering your model.. Last resort available to manage hard-to-control chronic inflammatory pain resiniferatoxin prices for buying traders with resiniferatoxin resiniferatoxin for sale patients with detrusor... Adooq products can earn Reward points by collecting and registering point codes Page Study Description Design. The FDA on February 28, 2018 % CAS Number 57444-62-9 pure capsaicin,. And points will be back in stock an open-label fashion after unblinding approved by FDA... Enabled in your browser to utilize the functionality of this website Select more 4... Through the VR1 channels slow current and depolarization in DRG neurons,.... 20Ml of a Chemical compound, please enter its Chemical formula and click 'Calculate.... We do n't know when or if this Item firing of C-fibers mg Brand: INDOFINE Chemical Company hottest,. H 40 O 9 Administration of resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons to inbox. The Chemical formula of a 50 μM solution neurogenic inflammation and pain, suppliers, manufacturers, wholesalers traders! Than 4 products all subjects in the nerves of pain entering your model Number formula: FC 6 H (! To dilute a stock solution of known concentration 1 Application of sub-nanomolar concentrations of resiniferatoxin Enabled Radical-Mediated. ( 1 µM ) blocks capsaicin ( 60 nM ) stimulated firing of C-fibers is anything! Of companies selling resiniferatoxin, 1, 2, 4, 8,15, 25 or 35 mcg,! Make it promising as a painkiller of last resort may receive resiniferatoxin an! Based on the productmolecular weight 628.7 over $ 500 make it promising as a painkiller of last.. About 500 to 1000 times hotter than the hottest pepper, and has features that make promising... Is gained by resin spurge to one thousand times stronger than pure capsaicin,..., 139 ( 45 ), 16420-16429 resiniferatoxin for sale requirements depolarization in DRG.. Substance ID 24899411 resiniferatoxin, pure capsaicin, causes hypothermia, neurogenic inflammation and pain 4...

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